Lawrence J. Marnett, Ph.D.

Lawrence J. Marnett, Ph.D., is the Director of the Vanderbilt Institute of Chemical Biology, Mary Geddes Stahlman Professor of Cancer Research, Professor of Biochemistry, and Professor of Chemistry.Marnett received his Ph.D. in Chemistry from Duke University in 1973 and did postdoctoral work at the Karolinska Institute and Wayne State University.   He began his academic career at Wayne State University where he rose through the ranks to Professor of Chemistry.   In 1989, he moved to Vanderbilt.   Marnett's research program focuses on the role of the enzyme cyclooxygenase-2 in cancer and inflammation as well as on the contribution of normal metabolism to the generation of DNA damage and mutation.   His group has used structure-based based approaches in conjunction with medicinal chemistry to design selective cyclooxygenase-2 inhibitors as potential anti-inflammatory, cancer preventive, and anti-angiogenic agents.   Included in the awards Marnett has received are The Wayne State University President's Award for Excellence in Teaching, the American Cancer Society Faculty Research Award, the Sigma Xi Research Award, the Michigan Association of Governing Boards Distinguished Faculty Award, the Wayne State University Distinguished Graduate Faculty Award, an Outstanding Investigator Award from the National Cancer Institute, the Harvey Branscomb Distinguished Professorship, and the Stanley Cohen Prize at Vanderbilt University.   He is a Fellow of the American Association for the Advancement of Science.   He is the author of over 310 research publications and 10 patents. He is the founding and current editor-in-chief of the American Chemical Society journal, Chemical Research in Toxicology. Marnett served as Associate Director of Basic Research of the Vanderbilt Ingram Cancer Center from 1993-2002 and was named Director of the Vanderbilt Institute of Chemical Biology in 2002.

Education:

B.S., Rockhurst College, cum laude , 1969

Ph.D., Duke University, 1973

Personal Information:

Born Kansas City, Kansas.   U.S. Citizen, Married, two children

Professional Positions:

Research Associate , Karolinska Institutet, 1973-1974

Research Associate , Wayne State University, 1974-1975

Assistant Professor Chemistry , Wayne State University, 1975-1980; Associate Professor of Chemistry , Wayne State University, 1980-1983; Professor of Chemistry , Wayne State University, 1983-1989

Mary Geddes Stahlman Professor of Cancer Research , Professor of Biochemistry , Professor of Chemistry , Vanderbilt University School of Medicine, 1989-present

Director , A.B. Hancock, Jr. Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, 1989-present

Associate Director for Basic Research Programs ,   The Vanderbilt-Ingram Cancer Center, 1993-2002

Director , Vanderbilt Institute of Chemical Biology, 2002-present

Awards and Honors:

Probus Club Award for Academic Achievement (1980)

Wayne State University President's Award for Excellence in Teaching (1980)

American Cancer Society Faculty Research Award (1982)

Sigma Xi Research Award (1986)

Wayne State University Distinguished Graduate Faculty Award (1988)

Michigan Association of Governing Boards Distinguished Faculty Award (1988)

Chair, Gordon Research Conference on Oxygen Radicals in Biology and Medicine (1990)

National Cancer Institute Outstanding Investigator Grant (1988-2001)

Outstanding Teacher, Vanderbilt University Medical Student Class (1994-95; 1995-96)

Fellow of the Society for Free Radical Biology and Medicine (1994)

Gerald Wogan Lecture, Massachusetts Institute of Technology (1998)

Rockhurst College Science Hall of Fame (1998)

Oakley Vail Lecture, Wake Forest University (1999)

Harvey Branscomb Distinguished Professor, Vanderbilt University (2000)

Stanley Cohen Prize, Vanderbilt University School of Medicine (2000)

Project Director, National Foundation for Cancer Research (2000-present)

Distinguished Lecture, National Institute of Environmental Health Sciences (2001)

Fellow of the American Association for the Advancement of Science (2002)

Faculty Teaching Award for Mentoring Postdoctoral Fellows and/or Residents in the Research Setting, Vanderbilt University School of Medicine (2002)

Dolan Boyd Pritchett Memorial Lecture, University of Pennsylvania (2003)

Golden Goggles Invitational Lecture Middle Tennessee State University (2003)

Nelson J. Leonard Distinguished Lectures, University of Illinois (2003)

Harry G. Day Lecture, Indiana University (2003)

Chair, Gordon Research Conference on Mutagenesis and Carcinogenesis (2004)

McEwen Lecture, Queens' University (2004)

Scientific Societies:

American Chemical Society, American Society of Biochemistry and Molecular Biology, American Association for the Advancement of Science, International Society for the Study of Xenobiotics, American Association for Cancer Research, Society of Toxicology , The Society for Free Radical Biology and Medicine

Honorary Societies:

Alpha Sigma Nu, Phi Lambda Upsilon, Sigma Xi

Editorial Activities:

Founding Editor-in Chief , Chemical Research in Toxicology,   1987-present

Member , Editorial Board, The Journal of Biological Chemistry, 1983-1987.

Member , Editorial Board, Archives of Biochemistry and Biophysics, 1984-1993

Member , Editorial Board, Cancer Research, 1985-1986.

Member , Editoral Board, Free Radical Biology and Medicine, 1985 -1994

Member , Editorial Board, Carcinogenesis, 1986-1988

Member , Editorial Board, Advances in Pharmacology, 1987-

Series Co-Editor , Prostaglandins, Leukotrienes, and Cancer,   Martinus-Nijhoff Publisher, 1984-1988

Member , Editorial Board, Redox Reports, 1994-1996

Member , Editorial Board, Free Radical Research, 2000-